100th anniversary of the discovery of insulin perspective: insulin and adipose tissue fatty acid metabolism

AC Carpentier - American Journal of Physiology …, 2021 - journals.physiology.org
insulin-mediated suppression of adipose tissue lipolysis is the … hepatic, not skeletal muscle
or adipose tissue insulin sensitivity … post-oral glucose tolerance test (OGTT) plasma glycerol …

Is insulin resistance tissue-dependent and substrate-specific? The role of white adipose tissue and skeletal muscle

D Calderón-DuPont, I Torre-Villalvazo… - Biochimie, 2023 - Elsevier
… Although obesity is the result of adipose tissue expansion, it is … in adipose tissue impairs
whole body glucose tolerance [26]. … of glycerol by lipolysis is not recaptured by adipose tissue, …

Insulin resistance in type 2 diabetes

M Roden, KF Petersen, GI Shulman - Textbook of diabetes, 2024 - Wiley Online Library
… of glucose tolerance preceding type 2 diabetes comes from … concentrations [47] in skeletal
muscle of type 2 diabetes … within adipose tissue, inhibit insulin- mediated lipolysis in white …

Insulin: The master regulator of glucose metabolism

L Norton, C Shannon, A Gastaldelli, RA DeFronzo - Metabolism, 2022 - Elsevier
… protein, skeletal muscle function is heavily reliant on the insulin-mediated uptake of glucose
and … through primary effects on adipose tissue lipolysis and free fatty acid (FFA) availability. …

Insulin-mediated suppression of fatty acid release predicts whole-body insulin resistance of glucose uptake and skeletal muscle insulin receptor activation

M Schleh, B Ryan, C Ahn, A Ludzki, D Van Pelt… - bioRxiv, 2024 - biorxiv.org
… of fatty acid (FA) release from 49 adipose tissue, 2) skeletal … is often exceptionally sensitive
to the anti-lipolytic effects of insulin… in obese youth: a syndrome of impaired glucose tolerance, …

[HTML][HTML] Role of human Kallistatin in glucose and energy homeostasis in mice

L Sandforth, S Brachs, J Reinke, D Willmes… - Molecular …, 2024 - Elsevier
… to obesity with normal glucose tolerance before and after 6 … , insulin-mediated suppression
of hepatic glucose production … , but glucose uptake into adipose tissue and skeletal muscle

[HTML][HTML] Diabetes mellitus and its metabolic complications: the role of adipose tissues

L Dilworth, A Facey, F Omoruyi - International journal of molecular …, 2021 - mdpi.com
… utilize insulin for insulin-mediated glucose transport into tissues, … resistance in the liver, fat,
and skeletal muscle tissue [21]. … , regulation of fat storage and energy, glucose tolerance, and …

[HTML][HTML] Trends in insulin resistance: insights into mechanisms and therapeutic strategy

M Li, X Chi, Y Wang, S Setrerrahmane… - Signal transduction and …, 2022 - nature.com
… mediators released by adipose tissue including adipokines, … uptake from blood into liver,
fat, and skeletal muscle cells. … in suppression of lipolysis in adipocytes by inhibiting adipose

Sexual dimorphism in cardiometabolic health: the role of adipose tissue, muscle and liver

GH Goossens, JWE Jocken, EE Blaak - Nature Reviews Endocrinology, 2021 - nature.com
… in adipose tissue distribution, adipose tissue, skeletal muscle … mass than men of the same
age and BMI. Premenopausal … fatty acid isotope tracer), reflecting adipose tissue lipolysis, …

Effects of a hypercaloric and hypocaloric diet on insulin-induced microvascular recruitment, glucose uptake, and lipolysis in healthy lean men

AL Emanuel, RI Meijer, J Woerdeman… - … and Vascular Biology, 2020 - Am Heart Assoc
… recruitment in skeletal muscle and adipose tissue. In addition, … in obesity and a prelude
to type 2 diabetes mellitus and … had normal glucose tolerance assessed by an oral glucose